Choosing to Transfer Embryos with Positive PGT Results
People that pursue preimplantation genetic testing for monogenic disorders (PGT-M) with in vitro fertilization (IVF) usually do so to avoid passing down a genetic risk to their biological children. They typically do this by choosing not to transfer embryos found to...
BRCA Testing…Think It’s Not For You? Think Again
Ever since Angelina Jolie shared with the world her BRCA status and her choice to undergo a prophylactic mastectomy, a growing number of women have asked: “Should I have BRCA testing too?” BRCA1 and BRCA2 are the genes that cause the two most common hereditary breast...
PGT for Hereditary Breast and Ovarian Cancer Syndrome
What is Hereditary Breast and Ovarian Cancer syndrome? While most cancer happens by chance (i.e. sporadic), about 5-10% of cancers are caused, in part, by inheriting a genetic variant from a parent that increases the risk for certain cancers over a person’s lifetime....
Are Adults Conceived Using Assisted Reproductive Technology At Higher Risk for Health Problems?
Background The option to conceive a child using assisted reproductive technology (ART), including in vitro fertilization (IVF), became available in the late 1970s. This means that the first children to be born following conceptions using ART are now in their forties....
Research Update – How Does Trophectoderm Biopsy Affect Newborns?
The use of preimplantation genetic testing (PGT) on embryos both for monogenic disorders (PGT-M) and for aneuploidy (PGT-A) has rapidly increased over the last decade. Based on preliminary data from the 2017 SART National Summary Report, 36% of all in vitro...
Maternal Effects of Trophectoderm Biopsy
The use of preimplantation genetic testing (PGT) both for monogenic disorders (PGT-M) and for fetal aneuploidy (PGT-A) has rapidly increased over the last decade. Based on preliminary data from the 2017 SART National Summary Report, 36% of all in vitro fertilization...
PGT for Sickle Cell Disease
What is sickle cell disease? Sickle cell disease (SCD), also called sickle cell anemia, is a common inherited blood disorder that affects men and women across the world. Most often, SCD occurs in people of African, Middle Eastern, Mediterranean, Indian, Caribbean,...
PGT for Neurofibromatosis
The nervous system is essentially the body’s electrical wiring system, made up of the brain and a complex connection of specialized cells called neurons that transmit signals between different parts of the body. They work together to control all of the body’s...
What is Autosomal Dominant Inheritance?
This infographic explains autosomal dominant (AD) inheritance. Hereditary cancer syndromes, Huntington disease, and neurofibromatosis are examples of AD conditions.